Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension.[2] It is a tablet taken by mouth.[2] Onset is typically within half an hour and the duration is up to 36 hours.[2]
Common side effects include headache, muscle pain, flushed skin, and nausea.[2] Caution is advised in those with cardiovascular disease.[2] Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss.[2] Tadalafil is not recommended in people taking nitrovasodilators such as nitroglycerin, as this may result in a serious drop in blood pressure.[2] Tadalafil is a PDE5 inhibitor which increases blood flow to the penis with sexual arousal.[2] It also dilates blood vessels in the lungs, which lowers the pulmonary artery pressure.[2]
Tadalafil was approved for medical use in the United States in 2003.[2] It is available as a generic medication in the United States and United Kingdom.[3] In the UK it costs the NHS about 0.80 £ per dose as of 2019.[3] In the United States the wholesale cost of this amount is about US$1.91.[4] In 2016 it was the 280th most prescribed medication in the United States with nearly 1.5 million prescriptions.[5]
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