Anastrozole, sold under the brand name Arimidex among others, is a medication used in addition to other treatments for breast cancer.[6][1] Specifically it is used for hormone receptor-positive breast cancer.[1] It has also been used to prevent breast cancer in those at high risk.[1] It is taken by mouth.[1]
Common side effects of anastrozole include hot flashes, altered mood, joint pain, and nausea.[1][6] Severe side effects include an increased risk of heart disease and osteoporosis.[1] Use during pregnancy may harm the baby.[1] Anastrozole is in the aromatase-inhibiting family of medications.[1] It works by blocking the production of estrogens in the body, and hence has antiestrogenic effects.[1]
Anastrozole was patented in 1987 and was approved for medical use in 1995.[7][8] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[9] Anastrozole is available as a generic medication.[1] The wholesale cost in the developing world is about US$1.92–30.60 a month.[10] In the United States the wholesale cost is about $3.81 per month.[11] In 2016, it was the 224th most prescribed medication in the United States, with more than 2 million prescriptions.[12]
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